Given: A one-one function from set $\{1,2,3\}$ to set $\{a,b,c,d,e\}$

Step 1: One-one (injective) function means no two elements map to the same output.

We choose 3 different elements from 5 and assign them to 3 inputs in order.

So, total one-one functions = $P(5,3) = 5 \times 4 \times 3 = 60$

✅ Final Answer: $\boxed{60}$